Tuesday, March 18, 2014

Inhaled Caffeine: Not a Good Option


Can’t live without your daily dose of caffeine? I know many people who will go out of the way just to grab a fresh cup of Joe or any caffeine shot to jump start their day or combat that afternoon lull.

Sometimes, that hot coffee isn’t readily available. (Where’s the Starbucks when you need one?) That’s why Massachusetts company Breathable Foods Inc. believes their new pocket-sized, inhalable caffeine shot may just be the answer. Called “AreoShot Pure Energy”, the product is a breathable energy product that delivers your caffeine in a single breath.

According to the product information, AeroShot also contains B vitamins with the caffeine and delivers energy immediately when the powder is inhaled through the mouth and then swallowed. The company states that each puff contains about 100 milligrams of caffeine, equivalent to one large cup of coffee; and that each $2.99 vial (small plastic tube the size of lipstick) contains up to six puffs.

The product was first developed for consumers in Paris, France, but was released as a supplement in two markets last year: Boston and New York. It is now available in many locations, including online markets.
While the product seems like a perfect solution for those caffeine addicts who cannot go without their Java, it has fallen under severe scrutiny by U.S. health officials, including the Food and Drug Administration. Just a few months after its release in the United States, health authorities believe the product is mislabeled and potentially unsafe. Because the product is being marketed as a dietary supplement, it is not regulated by the FDA; however, the Administration still provided a review and warning letter to the company.

First, the Administration mentioned that there is no product that can be both inhaled and ingested because of the functioning of the epiglottis, which keeps inhaling and swallowing as two separate bodily functions. If inhaled into the lungs, caffeine can cause significant health problems, particularly in the respiratory system. Research has shown that ground coffee is light enough to become airborne, and thus, is considered particulate matter. The health impact of inhaling particulates, even when they are chemically less toxic such as coffee grounds, can produce negative health issues because the particles can deposit deep into the lungs.

While most people think of engine exhaust and factory smoke as the root of all particulate matter, any foreign object found in the lungs is considered particulate matter and can significantly affect breathing capacity. Furthermore, one study found that inhaling caffeine is associated with abnormal psychiatric behaviors in people with mental health issues. Unfortunately, it is more likely that those who would attempt to inhale products for their “buzz” effect would have some sort of psychiatric disorder, even at a mild level. In healthy individuals, inhaled caffeine had mild effects. Long-term effects of caffeine inhalation have yet to be determined.

In the meantime, the consensus is that inhaling coffee – or anything that could deposit a foreign object into the bronchi – is not safe. 

Second, the product may entice teen users. AeroShot’s website indicates the product is not recommended for people under age 18, however, the product label itself states “not intended for people under 12.” While the intent may be there, the purchase can still be made by teens and youth.

So, who’s to say the product wouldn’t be inhaled through the nose or mouth to place the contents directly into the lungs for some sort of “high?” Fears that teens would be able to obtain a cheap buzz by inhaling an extensive amount of the product are valid.

If you are thinking about trying such a product, you may want to rethink your strategy. If you have children and teens at home, you might want to have that discussion about the negatives effects of inhaling any foreign substance.


References

Business Wire. (2012). Breathable Foods announces the retail launch of AeroShot Pure Energy. Retrieved from http://www.businesswire.com/news/home/20120117005100/en/Breathable-Foods%C2%AE-Announces-Retail-Launch-AeroShot-Pure.

Keil, C., Kassa, H., Brown, A., Kumie, A., & Tefera, W. (2010). Inhalation exposures to particulate matter and carbon monoxide during ethiopian coffee ceremonies in addis ababa: A pilot study. Journal of Environmental and Public Health, , 213960. Retrieved from http://search.proquest.com/docview/856025690?accountid=32521

U.S. health authorities warn against ‘inhalable caffeine’. (2012). Agence France-Presse. NewsBank.
Food and Drug Administration. (2012). FDA issues warning letter to makers of AeroShot “caffeine inhaler.” Retrieved from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm294874.htm.

Zandvliet, A. S., Huitema, A. D. R., de Jonge, M. E., den Hoed, R. Sparidans, R. W., Hendriks, V. M., van den Brink, W., van Ree, J. M. and Beijnen, J. H. (2005). Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine. Pharmacology & Toxicology, 96, 71-79. Doi: 10.1111/j.1742-7843.2005.pto960111.x.


Tuesday, March 4, 2014

Can Cats Help Curb Obesity?


Interesting studies have discovered that cats may actually help us with weight loss.

Research presented at the Biophysical Society Meeting in mid-February found that cats – specifically calico cats – could provide the key to help people lose weight. It was explained that calico cats, which contain patches of various colors of fur (orange, black and white), have unique X chromosomes that cause that patchwork color mode.

Apparently, the cats “have an orange fur color gene on one of their X chromosomes and a black fur color gene on the other, so that random silencing of one of the X’s in each cell creates their distinctive patchwork coats” explained Elizabeth Smith, one of the researchers from the University of California.

Considering that we have now mapped the entire DNA sequencing for humans, we may be able to figure out which specific genes on a chromosome can be silenced to help us lose weight. Body fat distribution has already been linked with the X-chromosomes in the human body, therefore, it seems theoretically possible to identify and deactivate the fat-causing chromosome.

According to the research, the location of specific genes is currently underway and it could be possible to turn off or on specific chromosomes to achieve the desired effect. If that actually occurs, we could essentially turn off the “fat” genes and reduce obesity.

The research is still in its infancy, but considering the scope of such a concept, there could be more results in the near future.

So, how safe is it to modify our genetic make-up in this fashion?

Considering we’ve really only begun to understand the complexities of our DNA, we may not have enough information to assess such a concept right now. The Genetics and Public Policy Center has outlined the ethical nature of gene modifications. According to the center, we have successfully modified genes in laboratory animals and some of those modifications could be transferred to a human being. So far, none of have been tried.

A trial run of replacing a defective embryonic stem cell with a normal one in mice was successful. Yet, doing so in a human being may lead to what scientists are calling unwanted mutations in the genes that could leave the person with severe development outcomes or dead. While this test was in reproductive genes, there could be similar consequences with messing with any of the genes in the human body –including deactivating fat genes to reduce obesity.

Furthermore, the Center noted that such modifications bring up the concept that people will be “playing God” and whether this should be approached at all.

Until more research is conducted on gene modifications or activating/deactivating genes, we should simply attempt to adopt safer and healthier alternatives to combat obesity such as eating healthy and exercising daily.


References

Baruch, S., Huang, A., Pritchard, Kalfoglou, A., Javitt, G., Borchelt, R., Scott, J., and Hudson, K. (2010). Human Germline Genetic Modification: Issues and options for policymakers. Retrieved from http://www.dnapolicy.org/pub.reports.php?action=detail&report_id=3.

Hays, B. (2014). Calico cats may hold secret to weight loss. UPT News Track (Consumer Health). Accession Number: 6E81843882796

Viegas, J. (2014). How calico cats could help cure obesity. Retrieved from http://news.discovery.com/animals/pets/how-calico-cats-could-help-cure-obesity-140218.htm.